LLP PUBLICATIONS 2006-2010

Global DNA hypomethylation-induced ?Np73 transcriptional activation in non-small cell lung cancer. Daskalos A, Logotheti S, Markopoulou S, Xinarianos G, Gosney JR, Kastania AN, Zoumpourlis V, Field JK, Liloglou T. Cancer Lett. 2011 Jan 1;300(1):79-86.PMID: 20926182

Detection of DNA methylation changes in body fluids. Liloglou T, Field JK. Adv Genet. 2010;71:177-207.PMID: 20933129

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Daskalos A, Oleksiewicz U, Filia A, Nikolaidis G, Xinarianos G, Gosney JR, Malliri A, Field JK, Liloglou T.Cancer. 2010 Nov 8. [Epub ahead of print]PMID: 21061352

Global DNA hypomethylation-induced ΔNp73 transcriptional activation in non-small cell lung cancer. Daskalos A, Logotheti S, Markopoulou S, Xinarianos G, Gosney JR, Kastania AN, Zoumpourlis V, Field JK, Liloglou T. Cancer Lett. 2011 Jan 1;300(1):79-86.PMID: 20926182



Detection of DNA methylation changes in body fluids. Liloglou T, Field JK. Adv Genet. 2010;71:177-207.PMID: 20933129



UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Daskalos A, Oleksiewicz U, Filia A, Nikolaidis G, Xinarianos G, Gosney JR, Malliri A, Field JK, Liloglou T.Cancer. 2010 Nov 8. [Epub ahead of print]PMID: 21061352



SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. Schmidt B, Liebenberg V, Dietrich D, Schlegel T, Kneip C, Seegebarth A, Flemming N, Seemann S, Distler J, Lewin J, Tetzner R, Weickmann S, Wille U, Liloglou T, Raji O, Walshaw M, Fleischhacker M, Witt C, Field JK.BMC Cancer. 2010 Nov 3;10:600.



Quantitative promoter methylation differentiates carcinoma ex pleomorphic adenoma from pleomorphic salivary adenoma. Schache AG, Hall G, Woolgar JA, Nikolaidis G, Triantafyllou A, Lowe D, Risk JM, Shaw RJ, Liloglou T. Br J Cancer. 2010 Dec 7;103(12):1846-51. Epub 2010 Nov 9.PMID: 21063414



DNA methylation epigenotypes in breast cancer molecular subtypes. Bediaga NG, Acha-Sagredo A, Guerra I, Viguri A, Albaina C, Ruiz Diaz I, Rezola R, Alberdi MJ, Dopazo J, Montaner D, de Renobales M, Fernández AF, Field JK, Fraga MF, Liloglou T, de Pancorbo MM. Breast Cancer Res. 2010 Sep 29;12(5):R77. [Epub ahead of print]PMID: 20920229



Associations between genes for KIRs and their ligands in human solid tumour patients. Al Omar S, Middleton D, Marshall E, Porter D, Xinarianos G, Raji O, Field JK, Christmas SE.Hum Immunol. 2010 Jul 2. [Epub ahead of print]PMID: 20600442 ]



Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients: the European Early Lung Cancer Project. Van den Berg RM, Brokx H, Vesin A, Field JK, Brambilla C, Meijer CJ, Sutedja GT, Heideman DA, Postmus PE, Smit EF, Snijders PJ.Int J Oncol. 2010 Aug;37(2):455-61.PMID: 20596673



Comparison of discriminatory power and accuracy of three lung cancer risk models. D'Amelio AM Jr, Cassidy A, Asomaning K, Raji OY, Duffy SW, Field JK, Spitz MR, Christiani D, Etzel CJ.Br J Cancer. 2010 Jun 29. [Epub ahead of print]PMID: 20588271



Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer. Logotheti S, Michalopoulos I, Sideridou M, Daskalos A, Kossida S, Spandidos DA, Field JK, Vojtesek B, Liloglou T, Gorgoulis V, Zoumpourlis V.FEBS J. 2010 Jun 7. [Epub ahead of print]PMID: 20528922



Incorporation of a genetic factor into an epidemiologic model for prediction of individual risk of lung cancer: the Liverpool Lung Project. Raji OY, Agbaje OF, Duffy SW, Cassidy A, Field JK.Cancer Prev Res (Phila Pa). 2010 May;3(5):664-9. Epub 2010 Apr 27.PMID: 20424129



EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration. Field JK, Liloglou T, Niaz A, Bryan J, Gosney JR, Giles T, Brambilla C, Brambilla E, Vesin A, Timsit JF, Hainaut P, Martinet Y, Vignaud JM, Thunnissen FB, Prinsen C, Snijders PJ, Smit EF, Sozzi G, Roz L, Risch A, Becker HD, Elborn JS, Magee ND, Montuenga LM, Pajares MJ, Lozano MD, O'Byrne KJ, Harrison DJ, Niklinski J, Cassidy A; EUELC Collaborators.Eur Respir J. 2009 Dec;34(6):1477-86.PMID: 19948914



Molecular features, markers, drug targets, and prospective targeted therapeutics in cardiac myxoma. Barh D, Kumar A, Chatterjee S, Liloglou T. Curr Cancer Drug Targets. 2009 Sep;9(6):705-16. Review.PMID: 19754355



Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Dunn J, Baborie A, Alam F, Joyce K, Moxham M, Sibson R, Crooks D, Husband D, Shenoy A, Brodbelt A, Wong H, Liloglou T, Haylock B, Walker C. Br J Cancer. 2009 Jul 7;101(1):124-31. Epub 2009 Jun 16.PMID: 19536096



A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang Z, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang Y, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metsapalu A, Vooder T, Nelis M, Välk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeböller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF Jr, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE.Am J Hum Genet. 2009 Nov;85(5):679-91. Epub 2009 Oct 15.PMID: 19836008



Use of lung cancer risk models in planning research and service programs in CT screening for lung cancer. Duffy SW, Raji OY, Agbaje OF, Allgood PC, Cassidy A, Field JK.Expert Rev Anticancer Ther. 2009 Oct;9(10):1467-72. Review.PMID: 19828008



Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Lips EH, Gaborieau V, McKay JD, Chabrier A, Hung RJ, Boffetta P, Hashibe M, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Field JK, Liloglou T, Xinarianos G, McLaughlin J, Liu G, Skorpen F, Elvestad MB, Hveem K, Vatten L, Study E, Benhamou S, Lagiou P, Holcátová I, Merletti F, Kjaerheim K, Agudo A, Castellsagué X, Macfarlane TV, Barzan L, Canova C, Lowry R, Conway DI, Znaor A, Healy C, Curado MP, Koifman S, Eluf-Neto J, Matos E, Menezes A, Fernandez L, Metspalu A, Heath S, Lathrop M, Brennan P.Int J Epidemiol. 2010 Apr;39(2):563-77. Epub 2009 Sep 23.PMID: 19776245



Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Shaw RJ, Omar MM, Rokadiya S, Kogera FA, Lowe D, Hall GL, Woolgar JA, Homer J, Liloglou T, Field JK, Risk JM.Br J Cancer. 2009 Jul 7;101(1):139-44.PMID: 19568272



A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene. Johnson GG, Sherrington PD, Carter A, Lin K, Liloglou T, Field JK, Pettitt AR.Cancer Res. 2009 Jun 15;69(12):5210-7. Epub 2009 Jun 2.PMID: 19491257



Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk: results from a multi-centre case-control study in Europe.Cassidy A, Balsan J, Vesin A, Wu X, Liloglou T, Brambilla C, Timsit JF, Field JK; EUELC Consortium.Eur J Cancer. 2009 Nov;45(17):3047-53. Epub 2009 May 29.PMID: 19482469



Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer. Knight LJ, Burrage J, Bujac SR, Haggerty C, Graham A, Gibson NJ, Ellison G, Growcott JW, Brooks AN, Hughes AM, Xinarianos G, Nikolaidis G, Field JK, Liloglou T.Int J Oncol. 2009 Feb;34(2):465-71.PMID: 19148482



Lung cancer risk models come of age. Field JK.Cancer Prev Res (Phila Pa). 2008 Sep;1(4):226-8. No abstract available. PMID: 19138964



Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.Verri C, Roz L, Conte D, Liloglou T, Livio A, Vesin A, Fabbri A, Andriani F, Brambilla C, Tavecchio L, Calarco G, Calabrò E, Mancini A, Tosi D, Bossi P, Field JK, Brambilla E, Sozzi G; EUELC Consortium.Am J Respir Crit Care Med. 2009 Mar 1;179(5):396-401. Epub 2008 Dec 18.PMID: 19096006



Sample size determination in clinical proteomic profiling experiments using mass spectrometry for class comparison. Cairns DA, Barrett JH, Billingham LJ, Stanley AJ, Xinarianos G, Field JK, Johnson PJ, Selby PJ, Banks RE.Proteomics. 2009 Jan;9(1):74-86.PMID: 19053145



International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P.Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3081-9.PMID: 18990748



Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T. Int J Cancer. 2009 Jan 1;124(1):81-7.PMID: 18823011



A global approach to cancer-screening trials. Smith RA, Field JK, Duffy SW.Lancet Oncol. 2008 Oct;9(10):908-9. Epub 2008 Sep 19. No abstract available. PMID: 18805732



Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF.Cancer Res. 2008 Sep 15;68(18):7448-56.PMID: 18794132



p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia. Hall GL, Shaw RJ, Field EA, Rogers SN, Sutton DN, Woolgar JA, Lowe D, Liloglou T, Field JK, Risk JM.Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2174-9.PMID: 18708411



Lung cancer screening: the way forward. Field JK, Duffy SW.Br J Cancer. 2008 Aug 19;99(4):557-62. Epub 2008 Jul 29. Review.PMID: 18665179



Generation of a non-small cell lung cancer transcriptome microarray. Tanney A, Oliver GR, Farztdinov V, Kennedy RD, Mulligan JM, Fulton CE, Farragher SM, Field JK, Johnston PG, Harkin DP, Proutski V, Mulligan KA.BMC Med Genomics. 2008 May 30;1:20.PMID: 18513400



A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field JK, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcátová I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway DI, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P.Nature. 2008 Apr 3;452(7187):633-7.PMID: 18385738



The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. Shaw RJ, Hall GL, Lowe D, Liloglou T, Field JK, Sloan P, Risk JM.Arch Otolaryngol Head Neck Surg. 2008 Mar;134(3):251-6.PMID: 18347248



The LLP risk model: an individual risk prediction model for lung cancer.Cassidy A, Myles JP, van Tongeren M, Page RD, Liloglou T, Duffy SW, Field JK.Br J Cancer. 2008 Jan 29;98(2):270-6. Epub 2007 Dec 18.PMID: 18087271



Seizure 6-like (SEZ6L) gene and risk for lung cancer. Gorlov IP, Meyer P, Liloglou T, Myles J, Boettger MB, Cassidy A, Girard L, Minna JD, Fischer R, Duffy S, Spitz MR, Haeussinger K, Kammerer S, Cantor C, Dierkesmann R, Field JK, Amos CI.Cancer Res. 2007 Sep 1;67(17):8406-11.PMID: 17804757



Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma. Shaw RJ, Hall GL, Woolgar JA, Lowe D, Rogers SN, Field JK, Liloglou T, Risk JM.Br J Oral Maxillofac Surg. 2007 Dec;45(8):617-22. Epub 2007 Jun 7.PMID: 17559992



The Liverpool Statement 2005: priorities for the European Union/United States spiral computed tomography collaborative group. Field JK, Smith RA, Duffy SW, Berg CD, van Klaveren R, Henschke CI, Carbone D, Postmus PE, Paci E, Hirsch FR, Mulshine JL.J Thorac Oncol. 2006 Jun;1(5):497-8.PMID: 17409906



CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology. Shaw RJ, Hall GL, Lowe D, Bowers NL, Liloglou T, Field JK, Woolgar JA, Risk JM.Oral Oncol. 2007 Oct;43(9):878-86. Epub 2007 Jan 25.PMID: 17257884



Occupational exposure to crystalline silica and risk of lung cancer: a multicenter case-control study in Europe. Cassidy A, 't Mannetje A, van Tongeren M, Field JK, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Fevotte J, Fletcher T, Brennan P, Boffetta P.Epidemiology. 2007 Jan;18(1):36-43.PMID: 17149143



Cytosine methylation profiles as a molecular marker in non-small cell lung cancer. Ehrich M, Field JK, Liloglou T, Xinarianos G, Oeth P, Nelson MR, Cantor CR, van den Boom D.Cancer Res. 2006 Nov 15;66(22):10911-8.PMID: 17108128



Lung cancer risk prediction: a tool for early detection. Cassidy A, Duffy SW, Myles JP, Liloglou T, Field JK.Int J Cancer. 2007 Jan 1;120(1):1-6. Review.PMID: 17058200



Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives. Cassidy A, Myles JP, Duffy SW, Liloglou T, Field JK.Br J Cancer. 2006 Nov 6;95(9):1288-90. Epub 2006 Sep 26.PMID: 17003779



Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer. Pateras IS, Apostolopoulou K, Koutsami M, Evangelou K, Tsantoulis P, Liloglou T, Nikolaidis G, Sigala F, Kittas C, Field JK, Kotsinas A, Gorgoulis VG.Int J Cancer. 2006 Dec 1;119(11):2546-56.PMID: 16988944



Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing. Shaw RJ, Akufo-Tetteh EK, Risk JM, Field JK, Liloglou T.Nucleic Acids Res. 2006 Jun 28;34(11):e78.PMID: 16807314



Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. Xinarianos G, McRonald FE, Risk JM, Bowers NL, Nikolaidis G, Field JK, Liloglou T.Hum Mol Genet. 2006 Jul 1;15(13):2038-44. Epub 2006 May 12.PMID: 16698880



Defining high-risk individuals in a population-based molecular-epidemiological study of lung cancer. Cassidy A, Myles JP, Liloglou T, Duffy SW, Field JK.Int J Oncol. 2006 May;28(5):1295-301.PMID: 16596247



Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. McRonald FE, Liloglou T, Xinarianos G, Hill L, Rowbottom L, Langan JE, Ellis A, Shaw JM, Field JK, Risk JM.Hum Mol Genet. 2006 Apr 15;15(8):1271-7. Epub 2006 Mar 1.PMID: 16510494



Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM.Br J Cancer. 2006 Feb 27;94(4):561-8.PMID: 16449996



The Liverpool Lung Project research protocol. Field JK, Smith DL, Duffy S, Cassidy A.Int J Oncol. 2005 Dec;27(6):1633-45.PMID: 16273220



Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Nature. 2005 Apr 14;434(7035):907-13.PMID: 15829965



Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas. Gorgoulis VG, Liloglou T, Sigala F, Korkolis D, Yannoukakos D, Papalambros E, Asimacopoulos PJ, Papavassiliou AG, Kotsinas A. Mutat Res. 2004 Nov 22;556(1-2):143-50.PMID: 15491642

 



































































































































































































































CONTACTS

Professor John K. Field

Research Director
Tel 0151 7948900
Fax 0151 7948989
Email J.K.Field@liverpool.ac.uk
Dr Triantafillos Liloglou
Lecturer, Biomarkers and Clinical Resources Group
Tel  0151 7948958

Fax 0151 7948989

T.Liloglou@liverpool.ac.uk

Janet Farley (job share with Gaynor Hunt)

Study Co-ordinator
Roy Castle Lung Cancer Research Programme, 200 London Road

Liverpool, L3 9TA

Tel  :   0151 794 8957
Fax:   0151 794 8999   

farleyj@roycastle.liv.ac.uk
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